diff --git a/hlw/diagnostic-record/index.js b/hlw/diagnostic-record/index.js
index 8b3c335..114107b 100644
--- a/hlw/diagnostic-record/index.js
+++ b/hlw/diagnostic-record/index.js
@@ -1121,6 +1121,15 @@ async function auditDiagnosis(item, db) {
     if (passList.length) {
       let successRxList = [];
       const auditTime = Date.now();
+      // uploadRx2His 内部会按处方 id 从 MongoDB 重新读取记录并生成 PDF，
+      // 因此不能只在内存 rx 对象中补签名，必须先写入数据库。
+      await db.collection("diagnostic-record").updateMany(
+        {
+          _id: { $in: passList.map(i => i.rx._id) },
+          status: status.init,
+        },
+        { $set: { pharmacistSignImg: pharmacistCAUserId } }
+      );
       const uploadResult = await Promise.all(passList.map(i => uploadRx2His({ ...i.rx, auditTime }, i.order)));
       uploadResult.forEach(i => {
         if (i.success) {
@@ -1465,7 +1474,7 @@ async function reUploadDiagnosticRecord({ _id }) {
     const data = await db
       .collection("diagnostic-record")
       .findOne({ _id: new ObjectId(_id) });
-      console.log(data)
+    console.log(data)
     if (!data) return { success: false, message: "处方不存在" };
     const base64 = await getpdfbase64({ id: data._id.toString() }, db);
     const payload = formatUploadRxData(data, { pdf: base64 });
diff --git a/hlw/prescription-pdf/index.js b/hlw/prescription-pdf/index.js
index 7c4ff34..c725cef 100644
--- a/hlw/prescription-pdf/index.js
+++ b/hlw/prescription-pdf/index.js
@@ -129,8 +129,11 @@ function safeDataImage(value) {
 }
 
 function getUploadRoot() {
-  // 与 upload.js 使用相同的共享上传目录，拒绝任意文件系统路径。
-  return path.resolve(__dirname, "../../../upload-files");
+  // 源码运行时：<repo>/hn-hlw-service/hlw/prescription-pdf -> <repo>/upload-files。
+  // esbuild 后 __dirname 为 /opt/apps（bundle_pro.js 所在目录），上传目录则为 /opt/apps/upload-files。
+  return process.env.IS_BUILDED === "YES"
+    ? path.resolve(__dirname, "../upload-files")
+    : path.resolve(__dirname, "../../../upload-files");
 }
 
 function getImageMimeType(buffer, contentType = "") {